Synthesis of New Bis - Phthalimide and Thalidomide Ester Derivatives , and Evaluation of their Cytotoxic Activity
نویسندگان
چکیده
The esterification reaction of trimellitic anhydride chloride TMAC 1 with N-(hydroxymethyl) phthalimide NHMP 2, N-(2-hydroxyethyl) phthalimide NHEP 3 or N-(hydroxymethyl) thalidomide NHMT 4 afforded novel cyclic imide-ester derivatives; phthaloyl-phthalic anhydride methyl ester PPAME 5, phthaloyl-phthalic anhydride ethyl ester PPAEE 6 and thalidomide-phthalic anhydride methyl ester TPAME 7, respectively. These novel derivatives appeared very useful to prepare number of new hybrid structure of substituted N, Nbis-phthalimide and phthalimide-thalidomide moieties with different amino acids. The cytotoxicity of all synthesized compounds were in vitro evaluated against Hep-G2 and MCF-7, which showed that phthalimide derivatives 6, 9b, 10d, 11 and 12 possess significant antitumor potency.
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